Six & Twenty Distillery

Step off Perry Avenue and you’re met with the hum of conversation swirling around a copper-topped bar, the scent of freshly toasted spice, and spirits poured with a craftsman's touch. Six & Twenty Distillery pulses with energy—part neighborhood haunt, part craft laboratory. Locals gather here for Whiskey Wednesdays, sipping inventive Old Fashioneds while catching up at communal tables or tucking into a chicken sandwich that outshines fast-food icons. The staff know their spirits and their guests by name, whether you’re on a deep-dive distilling tour where guides geek out over mash bills or simply dropping in for a custom cocktail. This is where Greenville’s creative heartbeat meets Southern hospitality—a space that easily morphs from after-work hangout to baby shower venue to the hub of a finance meet-up. Here, craft isn’t just about what’s in your glass; it’s about connection. The distillery doubles as a cultural anchor, bridging visitors and regulars alike through spirited storytelling and genuine warmth.